Top Clinical Insights: What You Need To Know About JAK Inhibitor Safety
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Clinical Practice
● The most common adverse effects of JAK inhibitors are upper respiratory
tract infection, headache, nasopharyngitis, nausea, and acne.
● The boxed warning on JAK inhibitors was based on a single study with rheumatoid arthritis patients that were 50 years old or older, with at least one additional cardiovascular risk factor and were on concomitant methotrexate, systemic corticosteroids and had an average BMI of 30.
● The safety profile of JAK inhibitors is almost certainly better for the usual
patient with skin disease versus patients with rheumatoid arthritis.
● There are no other drugs (other than prednisone) that are as effective as JAKi inhibitors across so many different diseases.