Immunology 101: Dermatology Pathways and Clinical Implications
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Clinical Practice
- The JAK STAT pathway is a key intracellular signal transduction pathway for inflammation, itch in atopic dermatitis.
- IL-31 is a cytokine that it is known to be involved in itching via signal activation on sensory nerve cells.
- Histamine is not the only mediator of chronic urticaria; cytokines, prostaglandins, and proteases also play a role in the disease.