Fundamentals of Immunology in Atopic Dermatitis
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Clinical Practice
Atopic dermatitis is often the first presentation in the atopic march, followed by food allergy, asthma, and rhinitis. There is ongoing research regarding the use of deliberate emollient use early in life in predisposed babies and reducing the risk of progression through the atopic march
Clinically normal appearing skin in atopic dermatitis patients still harbors markers of inflammation/inflammatory cytokine expression.
Consider IgE testing in patients where the diagnosis is not clear (sppongiotic/psorisasiform dermatitis on biopsy). If IgE is elevated, guide treatment towards Th2 directed therapeutics to manage itch.