Top Clinical Insights: JAK Inhibitors in Pediatric Dermatology Patients
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Clinical Practice
- Primary reasons to consider an oral JAK inhibitor include debilitating anxiety related to injections, comorbid disease (Alopecia Areata, Vitiligo, Irritable Bowel Disease), dupilumab adverse effects, and dupilumab failures.
- Patients with alopecia areata consistently demonstrate poorer health-related quality of life than controls, impact similar to atopic dermatitis and psoriasis.
- Consider using the term alopecia areata for totalis and universalis, as it is a continuum of the same disease.
- Tofacitinib is approved for Juvenile Idiopathic Arthritis ages 2+
- SALT score is a measurement of alopecia areata severity. The higher the score the worse the disease on a scale from 0-100.
- Consider adding oral Minoxidil when treating alopecia areata patients with a JAK inhibitor.